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Faecal calprotectin testing for differentiating amongst inflammatory and non-inflammatory bowel diseases: a systematic review and economic evaluation |
Waugh N, Cummins E, Royle P, Kandala NB, Shyangdan D, Arasaradnam R, Clar C, Johnston R |
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Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation Waugh N, Cummins E, Royle P, Kandala NB, Shyangdan D, Arasaradnam R, Clar C, Johnston R. Faecal calprotectin testing for differentiating amongst inflammatory and non-inflammatory bowel diseases: a systematic review and economic evaluation. Health Technology Assessment 2013; 17(55) Authors' objectives To review the value of FC for distinguishing between IBD and non-IBD. Authors' conclusions Faecal calprotectin can be a highly sensitive way of detecting IBD, although there are inevitably trade-offs between sensitivity and specificity, with some false positives (IBS with positive calprotectin) if a low calprotectin cut-off is used. In most cases, a negative calprotectin rules out IBD, thereby sparing most people with IBS from having to have invasive investigations, such as colonoscopy. Indexing Status Subject indexing assigned by NLM MeSH Adult; Child; Colonoscopy /adverse effects /economics; Cost-Benefit Analysis, Bibliographic; Diagnosis, Differential; Enzyme-Linked Immunosorbent Assay /economics; Feces /chemistry; Great Britains; Inflammatory Bowel Diseases /complications /diagnosis /economics; Irritable Bowel Syndrome /complications /diagnosis /economics; Leukocyte L1 Antigen Complex /analysis /economics; Middle Aged; Quality-Adjusted Life Years; Sensitivity and Specificity Language Published English Country of organisation England English summary An English language summary is available. Address for correspondence NETSCC, Health Technology Assessment, Alpha House, University of Southampton Science Park, Southampton, SO16 7NS UK Tel: +44 23 8059 5586 Email: hta@hta.ac.uk AccessionNumber 32013000935 Date abstract record published 12/12/2013 |
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