Record Status This is a bibliographic record of a published health technology assessment. No evaluation of the quality of this assessment has been made for the HTA database. Citation NanoKnife System (AngioDynamics Inc.) for irreversible electroporation treatment of primary and metastatic liver tumors. Lansdale: HAYES, Inc.. Healthcare Technology Brief Publication. 2014 Authors' objectives An estimated 33,190 individuals in the United States will be diagnosed with primary liver cancer in 2014 and nearly 23,000 will die from the disease. Surgery can cure early disease but most patients present with unresectable disease or multiple liver metastases from other cancers. Colorectal cancer (CRC) is metastatic at diagnosis in 20% of patients and is the most common indication for hepatic resection and the most common etiology of metastases to liver. For patients with unresectable metastatic CRC, radiofrequency ablation (RFA) of hepatic metastases is associated with improved survival and quality of life. Locoregional hepatocellular carcinoma (HCC) and metastatic CRC are currently treated with thermal ablation with RFA and microwave ablation (MWA). These methods heat the tissue, causing denaturation of proteins. Thermal ablation
methods heat the tissue, causing denaturation of proteins. The resultant zone of tissue destruction surrounding the intended target can damage normal liver tissue and nearby organs, hepatic ducts, and blood vessels, which leads to the need for alternative therapies. Indexing Status Subject indexing assigned by CRD MeSH Electrochemotherapy; Electroporation; Humans; Liver Neoplasms; Neoplasm Metastasis Language Published English Country of organisation United States English summary An English language summary is available. Address for correspondence HAYES, Inc., 157 S. Broad Street, Suite 200, Lansdale, PA 19446, USA. Tel: 215 855 0615; Fax: 215 855 5218 Email: hayesinfo@hayesinc.com AccessionNumber 32014000978 Date abstract record published 11/08/2014 |