Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation Malaysian Health Technology Assessment (MaHTAS). Photodynamic therapy for cancer treatment – an update. Putrajaya: Malaysian Health Technology Assessment (MaHTAS). 2013 Authors' objectives To assess the effectiveness, safety and cost-effectiveness of photodynamic therapy especially Next Generation Photodynamic Therapy (NGPDT) for the treatment of cancer.
Authors' conclusions There was no retrievable scientific evidence on the effectiveness, safety and cost effectiveness on the Next
Generation Photodynamic Therapy (NGPDT).
However, the retrieved evidence showed that there was limited, adequately powered RCT's on PDT. From the
above review it was found that:
- There was insufficient evidence on the use of PDT in oesophageal cancer, lung cancer, brain cancer and
cancers of the head and neck. Hence, further research into the role of PDT in these areas is needed.
- PDT has the potential and may be effective in the treatment of actinic keratosis (AK), nodular basal cell
carcinoma (BCC) and possibly for treating Barrett's oesophagus.
- For cholangiocarcinoma, PDT may improve survival when compared with stenting alone.
- For advanced and/or recurrent tongue base carcinoma, treatment was well tolerated by patients
and has potential in shrinking tumour and controlling further progression. Evidence suggests that 5-ALAPDT
and/or mTHPC-PDT may offer an effective alternative treatment for oral potentially malignant disorders.
- A wide variety of photosensitisers were used and, overall, no serious adverse effects were linked to PDT.
However caution should be taken on signs for Bruguda syndrome and buried neoplasms after PDT.
The effectiveness of PDT and NGPDT in relation to other treatments is not yet apparent. High quality trials are
warranted for PDT and NGPDT to establish their effectiveness and safety. INAHTA brief and checklist INAHTA brief and checklist Indexing Status Subject indexing assigned by CRD MeSH Humans; Neoplasms; Photochemotherapy; Photosensitizing Agents Language Published English Country of organisation Malaysia English summary An English language summary is available. Address for correspondence Health Technology Assessment Section, Ministry of Health Malaysia, Federal Government Administrative Centre, Level 4, Block E1, Parcel E, 62590 Putrajaya Malaysia
Tel: +603 888 312 29 Email: htamalaysia@moh.gov.my AccessionNumber 32016000306 Date abstract record published 24/02/2016 |