Record Status This is a bibliographic record of a published health technology assessment. No evaluation of the quality of this assessment has been made for the HTA database. Citation NIHR HSRIC. Sodium thiosulfate for prevention of hearing loss in children receiving cisplatin chemotherapy. Birmingham: NIHR Horizon Scanning Research&Intelligence Centre. Horizon Scanning Review. 2015 Authors' objectives Sodium thiosulfate is intended to be used to prevent hearing loss in children who receive cisplatin chemotherapy. It inactivates platinum complexes by binding electrophilic platinium with thiol, thus forming a covalent complex that is not cytotoxic and can be excreted rapidly. Sodium thiosulfate does not currently have Marketing Authorisation in the EU for any indication.
Cancer in children (aged 0-14 years) is rare compared with the adult population, accounting for less than 1% of all cancers. Cisplatin is a widely-used chemotherapeutic agent and is standard of care for a variety of paediatric malignancies. All children who receive cisplatin are at risk of cisplatin-induced hearing loss, and it occurs in at least 60% of treated patients. Hearing loss is likely to delay speech and language development in children and can have a significant impact on school performance and psychosocial functioning.
There are currently no treatment options available to prevent hearing loss in children receiving cisplatin chemotherapy. Sodium thiosulfate is currently in phase III clinical trials investigating its effect on hearing loss when administered alongside cisplatin chemotherapy. These trials are expected to complete in late 2015 and late 2017. Indexing Status Subject indexing assigned by CRD MeSH Child; Cisplatin; Deafness; Hearing Loss; Humans; Thiosulfates Language Published English Country of organisation England English summary An English language summary is available. Address for correspondence NIHR Horizon Scanning Research&Intelligence Centre, University of Birmingham, Institute of Applied Health Research, Public Health building, Edgbaston, Birmingham B15 2TT
Tel: 0121 414 9077 Email: nihrhsc@contacts.bham.ac.uk AccessionNumber 32016000330 Date abstract record published 03/03/2016 |