Record Status This is a bibliographic record of a published health technology assessment. No evaluation of the quality of this assessment has been made for the HTA database. Citation NIHR HSRIC. Vincristine liposomal (Marqibo) in combination with chemotherapy for elderly patients with newly diagnosed CD20 positive diffuse large B-cell lymphoma – first line. Birmingham: NIHR Horizon Scanning Research&Intelligence Centre. Horizon Scanning Review. 2015 Authors' objectives Diffuse large B-cell lymphoma is a cancer of white blood cells called lymphocytes that normally help the body to fight infections. Lymphoma is more common among older people. Treating older patients who often have other additional medical conditions can be a difficult task. Many of the drugs currently used for the treatment of lymphoma can have serious side effects.
Vincristine liposomal is a new form of a chemotherapy drug called vincristine that may be more effective and less toxic than current chemotherapy because it is encapsulated in a protective shell. It is delivered straight into the bloodstream via a drip. Some studies have suggested vincristine liposomal may be helpful for elderly people who have had no previous treatment for lymphoma and more studies are now aiming to show how well it works and whether it is safe to use.
If vincristine liposomal is licenced for use in the UK, it could be a new treatment option for newly diagnosed elderly patients with diffuse large B-cell lymphoma. It may improve survival and quality of life as it may cause fewer side effects than current treatments. Indexing Status Subject indexing assigned by CRD MeSH Aged; Humans; Liposomes; Lymphoma, Large B-Cell, Diffuse; Phospholipids; Vincristine Language Published English Country of organisation England English summary An English language summary is available. Address for correspondence NIHR Horizon Scanning Research&Intelligence Centre, University of Birmingham, Institute of Applied Health Research, Public Health building, Edgbaston, Birmingham B15 2TT
Tel: 0121 414 9077 Email: nihrhsc@contacts.bham.ac.uk AccessionNumber 32016000412 Date abstract record published 04/03/2016 |