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Botulinum toxin for sialorrhea |
Klappenbach R, Augustovski F, Pichon-Riviere A, García Martí S, Alcaraz A, Bardach A, Ciapponi A, López A, Rey-Ares L |
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Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation Klappenbach R, Augustovski F, Pichon-Riviere A, García Martí S, Alcaraz A, Bardach A, Ciapponi A, López A, Rey-Ares L. Botulinum toxin for sialorrhea. Buenos Aires: Institute for Clinical Effectiveness and Health Policy (IECS). Informe de Respuesta Rapida No. 496. 2016 Authors' conclusions Low-quality evidence shows that botulinum toxin, compared with placebo, might reduce sialorrhea at short term in patients refractory to initial hygienic-dietary and/or pharmacological treatment, and might have an efficacy similar to other pharmacological alternatives, with a lower incidence of mild adverse effects.
Regulatory agencies from Argentina, the United States and Europe approved the use of botulinum toxin but not for the treatment of sialorrhea (its use in this pathology is "off-label").
Most clinical practice guidelines consider the use of botulinum toxin as one of the therapeutic options for sialorrhea in patients refractory to initial treatment. The United States health insurers consulted cover botulinum toxin for those cases of sialorrhea refractory to initial treatment. The Latin American health systems consulted do not cover this technology for this indication.
Final publication URL www.iecs.org.ar Indexing Status Subject indexing assigned by CRD MeSH Botulinum Toxins, Type A; Humans; Sialorrhea Language Published Spanish Country of organisation Argentina English summary An English language summary is available. Address for correspondence Institute for Clinical Effectiveness and Health Policy, Viamonte 2146 - 3 Piso, C1056ABH Ciudad de Buenos Aires, Argentina Tel: +54 11 49 66 00 82 Fax:+54 11 49 53 40 58 Email: info@iecs.org.ar AccessionNumber 32016001116 Date abstract record published 25/11/2016 |
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