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Autologous chondrocyte implantation in the knee: systematic review and economic evaluation |
Mistry H, Connock M, Pink J, Shyangdan D, Clar C, Royle P, Court R, Biant L C, Metcalfe A & Waugh N |
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Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation Mistry H, Connock M, Pink J, Shyangdan D, Clar C, Royle P, Court R, Biant L C, Metcalfe A & Waugh N. Autologous chondrocyte implantation in the knee: systematic review and economic evaluation. Health Technology Assessment 2017; 21(6) Authors' objectives To assess the clinical effectiveness and cost-effectiveness of autologous chondrocyte implantation (ACI) in chondral defects in the knee, compared with microfracture (MF).
The surfaces of the bones in the knee are covered with articular cartilage, a rubber-like substance that is very smooth, allowing frictionless movement in the joint and acting as a shock absorber. The cells that form the cartilage are called chondrocytes. Natural cartilage is called hyaline cartilage. Articular cartilage has very little capacity for self-repair, so damage may be permanent. Various methods have been used to try to repair cartilage. ACI involves laboratory culture of cartilage-producing cells from the knee and then implanting them into the chondral defect. Authors' conclusions The evidence base for ACI has improved since the last appraisal by the National Institute for Health and Care Excellence. In most analyses, the incremental cost-effectiveness ratios for ACI compared with MF appear to be within a range usually considered acceptable. Research is needed into long-term results of new forms of ACI. Indexing Status Subject indexing assigned by CRD MeSH Chondrocytes; Cost-Benefit Analysis; Humans; Knee; Knee Joint; Orthopedic Procedures Language Published English Country of organisation England English summary An English language summary is available. Address for correspondence NETSCC, Health Technology Assessment, Alpha House, University of Southampton Science Park, Southampton, SO16 7NS UK Tel: +44 23 8059 5586 Email: hta@hta.ac.uk AccessionNumber 32017000143 Date abstract record published 13/02/2017 |
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