What are the epidemiological trends of dengue disease in Brazil from 2000 to the current date, particularly in the context of the regional trends?
What are the current gaps in our epidemiological knowledge of dengue disease in Brazil?
What are the future research needs, in preparation for the introduction of a vaccination programme for dengue disease?
On-line databases for medical literature:
•United States National Library of Medicine and the National Institutes of Health Medical Database (PubMED).
•Scientific Electronic Library Online (SciELO).
•Latin American and Caribbean Health Sciences Database (LILACS).
National and international reports and guidelines:
•World Health Organization (WHO) Library database (WHOLIS).
•Pan American Health Organization (PAHO) Headquarters Library database.
•Brazilian Ministry of Health.
On-line database for Brazilian postgraduate research and theses:
•Lay literature, conference papers and posters, etc.
Language: Only studies published in English, Portuguese or Spanish will be included.
Date range: Date limits will be set at 1 January 2000 to the date that searching begins.
Types of study to be included
No restriction by study design at search stage although single case study reports will be excluded during the selection process.
Condition or domain being studied
The epidemiology of Dengue disease (including Dengue fever, Dengue haemorrhagic fever, Dengue shock syndrome, Dengue vaccines, Dengue virus) in Brazil.
Populations and sub-groups at risk for Dengue disease and severe Dengue disease. No limits by sex or age. Inclusion of both indigenous and non-indigenous populations.
General epidemiology indicators (incidence, attack rate, seroprevalence).
Intensity of epidemics; frequency of hospitalization; and severe Dengue fever (including Dengue haemorrhagic fever/Dengue shock syndrome).
Impact of surveillance.
Review of incidence, attack rate and seroprevalence data in Brazil.
Description of existing surveillance systems and other relevant epidemiological information.
To describe the epidemiological trends of Dengue disease in Brazil from 2000 to the current date, particularly in the context of the regional trends.
Data extraction, (selection and coding)
The bibliographies of retrieved papers (including reviews and/or meta-analyses) that meet the inclusion criteria will be hand-searched to identify any references that may meet the selection criteria but that have been missed by the electronic searches.
Such references will be included in the final search selection providing that they meet the inclusion criteria.
On completion of the database searches, publications identified by the approved search strategy and/or by members of the review team will be included in the literature review based on the search limits.
Duplicate publication of data could lead to over-sampling. This may arise with use of meta-analyses and other reviews. In such cases the original, primary publication will be used and not the meta-analyses or reviews.
Risk of bias (quality) assessment
Although it is possible to judge the quality of epidemiological studies in general terms, the broad range of study types encompass such a wide variation that it may be difficult to assign articles to precise quality criteria. Nonetheless, a judgment about the overall quality of studies is desirable.
The requirement and definition for a quality assessment tool for the studies will be discussed within the review team.
Strategy for data synthesis
A descriptive synthesis is planned; the data will be evaluated according to overall epidemiological findings presented in the papers and be discussed in terms of regional and temporal trends.
Analysis of subgroups or subsets
While no subgroup or meta-analysis is planned, the review team will be interested to observe regional and sub-regional trends and will discuss these in a subgroup narrative as appropriate.
The key findings from the literature analysis will be published as a review article in a suitable peer-reviewed medical journal.
Contact details for further information
2 Ave Pont Pasteur,
69367 Lyon Cedex 07,
Organisational affiliation of the review
Dr Germano Ferreira, Sanofi Pasteur Dr Grenville Marsh, Sanofi Pasteur Dr Lucia Bricks, Sanofi Pasteur Dr Carlos Espinal, Sanofi Pasteur Dr João Bosco Siqueira, Jr, Universidade Federal de Goiás Dr Maria da Gloria Teixeira, Universidade Federal da Bahia Mr Graham Joint, Communigen
Details of any existing review of the same topic by the same authors
Anticipated or actual start date
01 July 2011
Anticipated completion date
31 May 2012
Sanofi Pasteur, Lyon, France
Conflicts of interest
Germano Ferreria, Grenville Marsh, Lucia Bricks and Carlos Espinal are employees of Sanofi Pasteur. Graham Joint is a Principal Writer employed by Communigen and funded by Sanofi Pasteur. João Bosco Siqueira, Jr. and Maria da Gloria Teixeira declare no conflict of interest.
Formal screening of search results against eligibility criteria
Risk of bias (quality) assessment
PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites.