Study designs of evaluations included in the review
Studies of any design were eligible for inclusion. The included studies were retrospective case series (cases reported to six U.S. poison centres between 1989 and 1991) and case reports.
Specific interventions included in the review
Studies of bupropion overdose were eligible for inclusion. The included studies were of bupropion ingestion, either alone or in combination with other drugs such as acetaminophen, aspirin, caffeine, cannabinoids, amphetamines, paroxetine, possibly lithium, carbamazepine, thioridazine, diphenhydramine, possibly benzodiazepine, fluoxetine, flurazepam and ethanol.
Participants included in the review
Studies of adults or children who had taken an overdose were eligible for inclusion.
Outcomes assessed in the review
Studies that assessed toxicity were eligible for inclusion. The review reported cardiotoxicity, hypotension and other symptoms experienced by the patients.
How were decisions on the relevance of primary studies made?
Both authors independently scanned titles and abstracts according to the inclusion criteria.