Cost per single-dose vial: asparaginase $52.38; pegaspargase $980.00. To these medication costs were added the various other costs for each of the three common protocols investigated. The total high-dosage, in-patient costs for these three protocols are as follows (readers should refer to the article for low-dosage and outpatient costs):
1. Hoelzer Protocol: asparaginase $6,130.70; pegaspargase $2,340.00; saving = $3,790.70.
2. Linker Protocol: asparaginase $9,194.72; pegaspargase $4,680.00; saving = $4,514.72.
3. Gottlieb Protocol: asparaginase $5,972.58; pegaspargase $2,340.00; saving = $3,632.58.