IQWiG. Osteodensitometrie bei primärer und sekundärer osteoporose. [Osteodensitometry in primary and secondary osteoporosis] Cologne: Institut fuer Qualitaet und Wirtschaftlichkeit im Gesundheitswesen (IQWiG). IQWiG-Berichte 73. 2010
The key question of the present report was whether women or men with primary or secondary osteoporosis (but without pre-existing osteoporotic fractures) benefit from a health care strategy containing a diagnostic procedure (osteodensitometry) for determining low BMD and an increased fracture risk, as well as containing subsequent treatment, compared to a strategy without such an intervention. Due to the lack of studies with certainty of results, no direct statement on the benefit or harm of a health care strategy containing osteodensitometry can be inferred.However, the data provide an indication of a benefit of osteodensitometry in post-menopausal women without pre-existing osteoporotic fractures in whom BMD is measured by means of central DXA measurement. This indication is inferred from evidence of an interaction between BMD and therapy effects. This evidence is largely based on the results of one study.For individual therapy options in the treatment of osteoporosis without clinically evident fractures, the data provide indications of harm caused by adverse events. However, the results on adverse events are based on analyses that also included women with pre-existing fractures.Due to the lack of studies, both the benefit and the harm from therapy monitoring by means of osteodensitometry are unclear and therefore not proven.No equivalent alternative for determining BMD and fracture risk was found that could be applied as a replacement for measurement by means of central DXA.For elderly men with suspected primary osteoporosis, the data provide proof of a statistical association between low BMD and an increased fracture risk. Regarding risk groups for secondary osteoporosis, the data provide neither an indication nor proof of such an association. It cannot be inferred from this finding that such an association does not exist.
Subject indexing assigned by CRD
Absorptiometry, Photon; Bone Density; Densitometry; Fractures, Bone /prevention & Osteoporosis; controls
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Date abstract record published