PROSPERO is an international database of prospectively registered systematic reviews in health and social care, welfare, public health, education, crime, justice, and international development, where there is a health related outcome. Key features from the review protocol are recorded and maintained as a permanent record. PROSPERO aims to provide a comprehensive listing of systematic reviews registered at inception to help avoid duplication and reduce opportunity for reporting bias by enabling comparison of the completed review with what was planned in the protocol.

PROSPERO is produced by CRD and funded by the National Institute for Health Research (NIHR).

Advisory group

PROSPERO was initiated and developed by CRD working with the support and guidance of an international advisory group:

David Moher
Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Canada; Department of Epidemiology and Community Medicine, Faculty of Medicine, University of Ottawa, Ottawa, Canada.
Davina Ghersi
Research Translation Branch, National Health & Medical Research Council, Canberra, Australia.
Gordon Dooley
Managing Director, Metaxis Ltd, Oxford, UK.
Lesley Stewart
Director of CRD, University of York, York, UK.
Mike Clarke
Centre for Public Health, Queen's University Belfast, Belfast, UK, (Chair)
Malcolm Macleod
Division of Clinical Neurosciences, College of Medicine and Veterinary Medicine, University of Edinburgh; Florey Neurosciences Unit, Melbourne, Australia; Collaborative Approach to Meta-Analysis and Review of Animal Data in Experimental Studies (CAMARADES).

The PROSPERO Advisory Group Statement of Founding Principles centres on free access both to register and search the database and being as inclusive as possible while achieving the key aims of avoiding duplication and minimising bias in systematic reviews.


The Advisory Board would like to thank Alison Booth, Jimmy Christie and Mark Pettigrew for their invaluable work in the development and implementation of PROSPERO.

Methodological research using PROSPERO data

PROSPERO is creating opportunities for methodological research. The information being collected and published in PROSPERO will be of interest to many. As a matter of courtesy and in order to avoid duplication of effort, we ask that anyone planning research using PROSPERO data provide us with brief details of their work so we can record it here. Publications or presentations that use information obtained from PROSPERO should cite and acknowledge PROSPERO as the source of data. We would appreciate receiving details of such publications so that we can link to them from these pages.