Support for prospective registration of systematic reviews

The following organizations have expressed their support for the prospective registration of systematic review protocol information:

National Institute for Health Research (NIHR)
"We are pleased to have supported the development of PROSPERO by the NIHR Centre for Reviews and Dissemination at York. PROSPERO provides the first online facility to register systematic reviews for research about health and social care, and it is important that it has been designed through widespread consultation to be used internationally to promote best practice around the world."

Professor Dame Sally Davies
Chief Medical Officer and Director General of Research & Development
Department of Health, England

"Serious deficiencies in health research publications undermine the robustness and reliability of the available evidence which impedes the development of systematic reviews. The prospective registration of systematic reviews and the availability of review protocols can increase transparency and reliability of ongoing research and prevent unnecessary duplication of effort thus helping to reduce waste in medical research.

The EQUATOR Network, an international initiative working to improve the reliability and value of health research literature by promoting good research reporting practices, wholeheartedly supports the aims of PROSPERO and encourages registration of systematic reviews."


"If systematic reviews are not registered, there is a real risk for potential duplication of effort in future research, as well as the introduction of potential bias if results – negative or positive – are not published. BioMed Central is therefore pleased to endorse PROSPERO as a means to overcome these problems and increase transparency in scientific and medical research. BioMed Central encourages its authors to register their systematic reviews before they start their research, and to include these details when submitting their manuscript."

BioMed Central

Canadian Institutes of Health Research (CIHR)

"CIHR strongly encourages the prospective registration of systematic reviews. By providing open access to registered systematic reviews, the PROSPERO register assists in increasing transparency in research outcome reporting. This freely accessible register helps avoid the duplication of efforts and promotes collaboration, while facilitating the translation of research results into improved health outcomes.”

Canadian Institutes of Health Research

International Network of Agencies for Health Technology Assessment (INAHTA)

“INAHTA Network strongly supports the registration of systematic reviews…in order to avoid duplication of efforts and create an extensive and well-updated database of [ongoing] systematic reviews…

I am looking forward to involve INAHTA member agencies in this process.”

Måns Rosén, Executive Secretary
International Network of Agencies for Health Technology Assessment

“Selective reporting of health research isn't just a nuisance, it's an ethical breach that can harm patients. PROSPERO's openly accessible register of systematic review protocols is already ensuring that the evidence base is more transparent, and the BMJ is delighted to support and promote this important registry.

Dr Fiona Godlee FRCP
Editor in Chief, BMJ

“PROSPERO is an essential resource for anyone who needs to know about the aims and methods of systematic reviews: often the most actionable kind of health research. BMJ Open aims to make studies, protocols, and raw research data more accessible, understandable, and usable and hence we're very pleased to support PROSPERO. Indeed, we ask all authors to give registration details when submitting systematic review protocols and completed reviews for publication.”

Dr Trish Groves,
Editor in Chief BMJ Open

PLoS - Public Library of Science

“With a clear system in place for registration of new and ongoing systematic reviews, PLoS Medicine announces its support for this initiative. The journal wishes to promote best practice in the conduct and reporting of systematic reviews. Best practice includes registration during the protocol phase in PROSPERO or other appropriate registry, conduct of the review in accordance with a fully developed protocol, and reporting in line with the PRISMA guidelines. PLoS Medicine and other PLoS journals will now start asking authors on submission whether registered their systematic review…”

Virginia Barbour, Jocalyn Clark, Susan Jones, Melissa Norton, Emma Veitch,
The PLoS Medicine Editors

The Cochrane Collaboration

The Cochrane Collaboration is happy to support the PROSPERO initiative aimed at producing an open access, prospective register of systematic reviews. We believe that this initiative supports our mission to ensure that decision makers within health systems have access to credible, high quality information in order to inform their deliberations. The register will also support objectives that are core principles of The Cochrane Collaboration, including those that reflect the importance of identifying and minimising bias, and reducing unwarranted duplication of effort.”

Dr David Tovey FRCGP
Editor in Chief, The Cochrane Library

The Campbell Collaboration

“We are happy to confirm the Campbell Collaboration’s support for the initiative of establishing an international register of ongoing systematic reviews…

We recognize the utility of a register of this kind, and we particularly welcome the intention to offer free public access.“

Howard White, CEO
Campbell Collaboration

“As a not for profit international collaboration with a focus on producing reviews for health care, The Joanna Briggs Institute (JBI) is very keen to support and participate with this project”

Professor Alan Pearson,
Executive Director, The Joanna Briggs Institute

“The Head and Neck Optical Diagnostics Society (HNODS) support the initiative of launching a central international register of on-going systematic reviews. This is of the utmost importance to avoid duplication of efforts. We are in full support of PROSPERO and encourage our members to use this transparent openly accessible register of systematic reviews”

Waseem Jerjes BDS MBBS MSc PhD
On behalf of HNODS, Founding and Council Member

“Public Health Wales wholeheartedly supports the aims of this open central register initiative and is pleased to see that one of the initial criteria for inclusion will be systematic reviews on the wider determinants of health. The international register…will provide a valuable service to the public health community.”

Professor Sir Mansel Aylward CB, Chair,
Public Health Wales


“My Agency - founding member of the Guidelines International Network and of the German Network for EBM - supports the principle of prospective systematic review registration.

I am grateful for your initiative.”

Günter Ollenschläger, Prof., FRCPE, FACP
Head, German Agency for Quality in Medicine (ÄZQ)

WHO | The Alliance for Health Policy and Systems Research

The Alliance has led a consultative process exploring its potential role in generating and facilitating international collaboration for synthesizing Health Policy Systems Research. The draft report includes the recommendations for the Alliance that have emerged, which includes advocating and support for prospective registration of all protocols for systematic reviews when they are planned.

WHO | The Alliance for Health Policy and Systems Research


"PROSPERO is a much needed resource which facilitates prospective
registration of systematic reviews. The intuitive registration form is well
tailored to the specific features of a systematic review and overcomes the
difficulties associated with registering reviews on a standard trial

Dr Lisa Askie,
Manager of the Australian New Zealand Clinical Trials Registry (ANZCTR)


"The Guidelines International Network (G-I-N) promotes systematic development of clinical practice guidelines and reduction of duplication of efforts. The principle of prospective registration of systematic reviews can also participate to these goals and G-I-N supports it."

Philip van der Wees, PhD, PT
Chair, Guidelines International Network (G-I-N)

The James Lind Alliance
The James Lind Alliance

"In 2009, a paper published in the Lancet estimated that 85% of the massive global expenditure on medical research was being wasted.  As it is the public that, one way or another, is mainly responsible for funding medical research, this waste is a real scandal. One widespread form of waste results because researchers and research funders don't review systematically what is known already before embarking on additional research. The result is that resources are invested in poorly designed or frankly unnecessary research.  PROSPERO will help to address this problem, and to avoid inadvertent duplication of effort in preparing systematic reviews."

Sir Iain Chalmers
The James Lind Alliance

"BiONorte-Health Sciences Basque Association, from Spain, is very proud to support and participate with PROSPERO project. BiONorte encourages to authors to registry their future reviews and protocols before they start their researches in an open access database. PROSPERO offer us an interesting tool which increase the transparency and reliability of systematic reviews."

BiONorte (Health Sciences Basque Association)

"Although systematic reviews of clinical trials are well established, this methodology is increasingly used for synthesis of evidence from preclinical animal studies. As for clinical systematic reviews, prospective documentation of the preclinical review topic, planned methodology and any proposed subgroup analyses is of vital importance to increase transparency and reduce the risk of bias. Furthermore, registration can prevent unnecessary duplication. We are delighted that PROSPERO has been so receptive to the idea of expanding their scope to include registration of preclinical systematic review protocols! We have worked with PROSPERO to establish a registration form tailored to this type of review, and we look forward to seeing it being used widely.”

Kim Wever, Malcolm Macleod, Carlijn Hooijmans and Marc Avey The SYRCLE-CAMARADES protocol task force

“PROSPERO aims to reduce unplanned duplication and promote efficient use of resources. PROSPERO makes changes to the protocol transparent to reduce the risk of data-driven questions generating false conclusions. BJOG recommends registration with PROSPERO for all systematic reviews, and has published an editorial to underline the importance of registration to improve the transparency and rigour of secondary research.”


Dimitrios Siassakos - Executive BJOG Editor, on behalf of the Editorial Board

Other organisations are invited to contact us by email using the details on the contact page to add their support to the principle of prospective systematic review registration.