The review addressed a clear question using relevant inclusion criteria. The search was limited in scope and restricted to English language publications, so it was possible that relevant trials could have been omitted. Publication bias was not assessed and could not be ruled out given the subject area of the review. Limited details of review methods were reported, so the risk of reviewer error or bias was unclear. Quality of the included trials was not formally assessed, although details of blinding were reported, which meant the risk of bias in trials was unclear.
The authors' decision to present a narrative synthesis was reasonable, although the vote counting approach adopted meant that all trials were weighted equally regardless of sample size and quality. The limited quantitative data presented made it difficult to assess the clinical significance of the findings.
Despite these limitations, the authors' main conclusion relating to haloperidol reflects the evidence presented and appears reliable. Limitations in the evidence base make its generalisability to other drugs uncertain.