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Rituximab para el tratamiento de la púrpura trombocitopénica inmune crónica [Rituximab for the treatment of chronic immune thrombocytopenic purpura] |
Pichon Riviere A, Augustovski F, Garcia Marti S, Glujovsky D, Alcaraz A, Lopez A, Bardach A, Ciapponi A, Rey-Ares L |
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Record Status This is a bibliographic record of a published health technology assessment from a member of INAHTA. No evaluation of the quality of this assessment has been made for the HTA database. Citation Pichon Riviere A, Augustovski F, Garcia Marti S, Glujovsky D, Alcaraz A, Lopez A, Bardach A, Ciapponi A, Rey-Ares L. Rituximab para el tratamiento de la púrpura trombocitopénica inmune crónica. [Rituximab for the treatment of chronic immune thrombocytopenic purpura] Buenos Aires: Institute for Clinical Effectiveness and Health Policy (IECS). Informe de Respuesta Rápida N° 259. 2012 Authors' objectives To assess the available evidence on the efficacy, safety and coverage related aspects regarding rituximab use for patients with ITP. Authors' conclusions No studies of good methodological quality were found on rituximab for patients with ITP. Nonetheless, several case series suggest it is effective for the treatment of patients with chronic ITP refractory to standard treatment with an acceptable toxicity profile. Since there is no comparator, part of the effect attributed to rituximab could caused by spontaneous remission, present in 20-50% of these patients during their disease evolution. Lastly, rituximab is considered one of the possible second line treatments in the clinical practice guidelines in different countries worldwide, among which is Argentina. Indexing Status Subject indexing assigned by CRD MeSH Antibodies, Monoclonal, Murine-Derived; Purpura, Thrombocytopenic, Idiopathics Language Published Spanish Country of organisation Argentina English summary An English language summary is available. Address for correspondence Institute for Clinical Effectiveness and Health Policy, Viamonte 2146 - 3 Piso, C1056ABH Ciudad de Buenos Aires, Argentina Tel: +54 11 49 66 00 82 Fax:+54 11 49 53 40 58 Email: info@iecs.org.ar AccessionNumber 32014000307 Date abstract record published 31/01/2014 |
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