Randomised controlled trials (RCTs) were eligible for inclusion if they examined the effect of domperidone in puerperal women experiencing insufficient breast milk production. Any definition of insufficient lactation was eligible. Comparator treatments had to be placebo or no treatment. The main review outcome was percent change in daily breast milk volume after domperidone treatment.
All mothers were recruited a few weeks postpartum; only one study specifically mentioned providing extensive lactation counselling. All studies were placebo-controlled and used domperidone at a dose of 30mg/d (10mg orally, three times). Duration of treatment ranged from seven to 14 days. Studies assessed milk volume either by infant weight (when full-term infants were breast-fed directly) or by the amount of milk expressed (when a pump was used for pre-term infants). Studies were published between 1985 and 2010.
Two reviewers independently selected studies for inclusion, with disagreements resolved by discussion.